-Advise parents or caregivers that the symptoms of digoxin toxicity in pediatric patients may include weight loss, failure to thrive in infants, abdominal pain, and behavioral disturbances. -Instruct the patients to monitor and record their heart rate and blood pressure daily. Digoxin Dosage Your healthcare provider will prescribe a dosage of digoxin based on the condition being treated and other medications you are taking, among other factors. This medication comes in tablet, oral liquid, and injectable forms. Digoxin is used to treat heart failure, usually along with other medications. Learn about side effects, drug interactions, dosages, warnings, and more. These dosage schedules are meant as guidelines and careful clinical observation and monitoring of serum digoxin levels (see Section 4.4) should be used as a basis for adjustment of dosage in these paediatric patient groups. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of digoxin from your body, which may affect how digoxin works. Tables 3 and 5 provide the usual daily maintenance dose requirements for digoxin based on creatinine clearance [see Dosage and Administration (2.3)]. Digoxin is primarily excreted by the kidneys; therefore, patients with impaired renal function require smaller than usual maintenance doses of digoxin [see Dosage and Administration (2.3) ]. Tables 3 and 5 provide the usual daily maintenance dose requirements for digoxin based on creatinine clearance [see Dosage and Administration (2.3)]. Digoxin is primarily excreted by the kidneys; therefore, patients with impaired renal function require smaller than usual maintenance doses of digoxin [see Dosage and Administration (2.3)]. For oral dosage form (solution): Adults, teenagers, and children 10 years of age and older—Dose is based on age, body weight, and medical condition and must be determined by your doctor. At first, the dose is usually 10 to 15 micrograms (mcg) per kilogram (kg) of body weight. The digoxin dose received through breastfeeding is up to 4% of the neonatal maintenance dosage, which is unlikely to be clinically relevant There are no data on the effects of digoxin on the breastfed infant or the effects on milk production The doses of digoxin tablets used in controlled trials in patients with heart failure have ranged from 125 to 500 mcg once daily. In these studies, the dose has been generally titrated according to the patient's age, lean body weight, and renal function. Therapy is generally initiated at a dose of 250 mcg once daily in patients under age 70 with good renal function.